New developments in personalized medicine.
Genetic treatment plus exercise reverses fatigue in mice with muscle wasting disease
Adding exercise to a genetic treatment for myotonic dystrophy type 1 was more effective at reversing fatigue than administering the treatment alone in a study using a mouse model of the disease. In fact, exercise alone provided some benefit whereas the genetic treatment alone did not. This study has implications for patients with fatigue due to genetics-related musculoskeletal diseases and other types of illness-induced fatigue.
Solving a mystery: How the TB bacterium develops rapid resistance to antibiotics
These slow growing bacteria have long puzzled TB researchers with their fairly rapid resistance to antibiotics. Researchers may have been barking up the wrong tree in exploring genetics, because the answer seems to lie in the epigenetic domain.
Revolutionary CRISPR-based genome editing system treatment destroys cancer cells
Researchers have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries a genetic messenger (messenger RNA), which encodes for the CRISPR enzyme Cas9 that acts as molecular scissors that cut the cells' DNA.